PIPELINE

Corestem is a biopharmaceutical company that researches and commercializes stem cell technology.

Systemic Lupus Erythematosus ( SLE )

  • Development stage
    First-phase clinical trial completed
  • Mechanisms of action
    Immune response control, anti-inflammatory action and reduction of autoantibody generation through regulating the activity of immune cells
  • Injection route
    Intravenous injection

Systemic Lupus Erythematosus (SLE) is a representative autoimmune disease that affects almost all organs. It is an autoimmune disease that occurs more frequently in women than in men. These autoimmune diseases are damage caused by immune cells and immune antibodies that protect the body attacking one's own healthy tissue. Lupus symptoms are caused by abnormal autoantibodies that touch their own tissues and organs, causing inflammation and damage.

lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythema (SLE). Urine tests are done for all patients suspected of having SLE due to no signs of developing any specific disease. Kidney disease caused by lupus can worsen over time, leading to kidney failure. Lupus nephritis is one of the most serious symptoms of SLE because it is the leading cause of death within 10 years of disease. Although it has an incidence rate of more than 50% among lupus patients, no treatment has been developed for lupus nephritis.
It has now completed phase 1 clinical trials. It is intended for patients with lupus nephritis based on the pathogenesis. It is expected to treat lupus nephritis by regulating the activation of immune cells and reducing the production of autoantibodies through the anti-inflammatory effect and immune function control.

Lupus hemostatis is a condition in which blood vessels are inflamed. Inflammation is a condition in which tissues are damaged by blood cells entering the tissues. Lupus hemostatitis is one of the most frequent and most frequent inflammatory diseases in people with lupus. It is accompanied by a decrease in platelets and mainly causes symptoms of anemia.